Ingredient Science & Performance
47 deep dives into the neuroscience, clinical evidence, dose validation, and mechanisms behind every active compound in APEX and RESET.
The only form of magnesium clinically proven to cross the blood-brain barrier, increasing synaptic density and supporting cognitive flexibility in aging and healthy adults.
Patented whole coffee fruit extract shown in human RCTs to raise plasma BDNF levels by up to 143% — the key protein governing neuroplasticity and long-term memory formation.
Standardized Oroxylum indicum bark extract showing preclinical evidence for BDNF upregulation and dopaminergic activity — a novel neurotrophin support ingredient.
A rare amino acid with its own cellular transporter, increasingly recognized as a longevity nutrient for its exceptional antioxidant and mitochondrial protective properties in neural tissue.
APEX uses a dual-source caffeine architecture — whole coffee extract plus anhydrous — to achieve a smooth, sustained adenosine blockade without the spike-and-crash of isolated caffeine.
The calming amino acid from green tea synergizes with caffeine to produce focused alpha-wave activity within 40 minutes, eliminating jitteriness without reducing alertness.
Two next-generation alkaloids that extend and enhance the caffeine effect via adenosine and dopamine pathways — with no tolerance development observed over 8 weeks of daily use.
C8 caprylic acid is the most rapidly converted MCT to ketones, providing direct mitochondrial fuel for neurons — supporting sustained mental energy without blood sugar fluctuation.
The direct precursor to dopamine, norepinephrine, and epinephrine. Fermented for superior purity, it selectively replenishes catecholamine reserves under stress without stimulant effects.
The active adaptogen from Rhodiola rosea, isolated at 98.5% purity via fermentation — delivering 3-10x the salidroside of standard extracts for robust HPA-axis modulation.
The bioactive form of folate bypasses the MTHFR enzyme — relevant for the ~40% of the population with polymorphisms — ensuring full methylation cycle support for neurotransmitter synthesis.
Methylcobalamin is the neurologically active form of B12, supporting myelin integrity, homocysteine clearance, and linked in trials to significantly slower brain volume loss.
CDP-choline is the most clinically studied choline source, raising both acetylcholine and phosphatidylcholine levels — with trials showing a 14% increase in frontal lobe ATP and improved attention.
Patented American Ginseng standardized for ginsenosides, with multiple human RCTs demonstrating improvements in working memory, accuracy, and sustained attention at the 200 mg dose.
A nucleotide that crosses the blood-brain barrier and contributes to membrane phosphatidylcholine synthesis, with preclinical data showing up to 30% increases in dendritic spine density.
The only nutrient known to stimulate mitochondrial biogenesis — the actual growth of new mitochondria — making it uniquely important for long-term cognitive energy capacity.
The acetylated form of carnitine crosses the blood-brain barrier, supporting fatty acid transport into mitochondria and acetylcholine synthesis — with trials showing a 44% reduction in mental fatigue.
The sodium salt of the biologically active R-isomer of alpha lipoic acid, offering approximately 40x superior bioavailability over conventional racemic ALA for mitochondrial antioxidant defense.
A patented complex of arginine and silicon that consistently raises plasma nitric oxide in four independent RCTs at exactly the 1,500 mg dose used in APEX, improving cerebral blood flow and attention.
A high-flavanol cocoa extract standardized for theobromine and epicatechin, shown to increase cerebral blood flow by 8% and improve working memory in young healthy adults.
The most studied lutein brand in eye and brain research, delivering the 10 mg dose validated in AREDS2 and cognitive trials — accumulating in both the macula and cortical grey matter.
A simple but overlooked morning alkalizing electrolyte that supports acid-base balance, gastric comfort, and rehydration — relevant for cognitive performance within the first hour of waking.
True Ceylon cinnamon extract, shown in meta-analyses to reduce fasting glucose by 18-29% — supporting stable blood sugar and avoiding the cognitive impairments associated with postprandial glucose spikes.
Pyridoxal-5-phosphate is the coenzyme form of B6, directly active in over 140 enzymatic reactions including GABA, serotonin, dopamine, and melatonin synthesis — present in both APEX and RESET.
A dual-benefit magnesium form that delivers both elemental magnesium and malic acid as a Krebs cycle substrate — supporting mitochondrial ATP production and neuromuscular function across APEX and RESET.
A patented blend of Panax notoginseng and Astragalus membranaceus root extracts shown to increase the absorption of amino acids, vitamins, and other nutrients by up to 67% via intestinal transporter upregulation.
A clinically standardized holy basil extract with an extraordinary track record: 24 out of 24 published studies show statistically significant cortisol reduction and stress adaptation benefits.
Phosphatidylserine is a phospholipid essential for neuronal membrane integrity, with consistent RCT evidence showing cortisol modulation and cognitive preservation under physical and psychological stress at 300 mg.
Unlike synthetic GABA, PharmaGABA is naturally fermented Lactobacillus hilgardii, with evidence for crossing the blood-brain barrier and increasing relaxation alpha-wave activity by approximately 50%.
Standardized for rosmarinic acid, a potent GABA-transaminase inhibitor that raises endogenous GABA levels — with clinical trials showing up to 42% reduction in insomnia symptoms.
Honokiol from magnolia bark acts as a positive allosteric modulator of GABA-A receptors through a benzodiazepine-independent binding site — inducing sleep without the dependence risk of pharmaceutical sedatives.
Albion's TRAACS-certified magnesium bisglycinate uses the PepT1 di/tripeptide transporter for superior intestinal absorption, delivering high-dose elemental magnesium for NMDA receptor modulation and deep sleep support.
Award-winning saffron extract standardized for safranal and crocins, with multiple RCTs demonstrating mood improvement and sleep quality enhancement at 30 mg — and one head-to-head trial showing equivalence to an SSRI.
Zinc is the essential cofactor for arylalkylamine N-acetyltransferase (AANAT), the rate-limiting enzyme in melatonin synthesis — making this chelated, high-bioavailability form critical to healthy sleep onset.
Montmorency tart cherry concentrate providing naturally occurring melatonin, anthocyanins, and tryptophan — with IDO inhibition preventing the conversion of tryptophan away from the serotonin/melatonin pathway.
L-serine is the precursor to phosphatidylserine, sphingolipids, glycine, and D-serine — participating in 5 critical neurological pathways and showing neuroprotective effects in emerging clinical research.
Taurine functions as an inhibitory neurotransmitter, neuromodulator, osmoregulator, and mitochondrial protector — with a landmark 2023 Nature paper identifying it as a potential geroprotector that reverses age-related decline in model organisms.
Glycine lowers core body temperature by dilating peripheral blood vessels — triggering one of the most powerful biological sleep onset signals. A 2012 RCT (Bannai et al.) confirmed it reduces sleep latency and improves SWS quality.
A lysophospholipid-form DHA derived from algae, uniquely transported across the blood-brain barrier via the Mfsd2a transporter — achieving brain DHA uptake impossible with standard triglyceride fish oil at the same dose.
PEA is an endogenous lipid mediator that reduces neuroinflammation through PPAR-α activation and mast cell downregulation — with over 30 clinical trials and a unique property of showing no tolerance development over long-term use.
One of the most studied branded ingredients in existence, Pycnogenol has over 160 published studies demonstrating endothelial nitric oxide production, free radical scavenging, and cognitive benefits in aging populations.
The acetylated form of glutathione is far more bioavailable than reduced GSH, surviving gastric digestion and entering cells directly to replenish the master antioxidant during the overnight repair window.
Selenium is the essential cofactor for glutathione peroxidase 1 (GPx1) and 24 other selenoproteins involved in antioxidant defense, thyroid function, and DNA repair — making it irreplaceable in the overnight recovery stack.
Copper is the cofactor for Cu/Zn-superoxide dismutase, the primary cytosolic antioxidant enzyme. Included in RESET to balance the high zinc dose and prevent the copper depletion that can occur with long-term zinc supplementation.
Phytosomal CoQ10 with 3x superior bioavailability vs standard ubiquinone, supporting mitochondrial electron transport and membrane antioxidant defense — with cardiovascular outcome data from the landmark Q-SYMBIO trial.
Fermentation-derived astaxanthin is the most powerful lipophilic antioxidant known, with in vitro singlet oxygen quenching 6,000x greater than vitamin C — and unique ability to span the full cell membrane bilayer.
A comprehensive digestive enzyme blend covering all 5 major enzyme classes — protease, lipase, amylase, cellulase, and lactase — ensuring maximum absorption of the 24+ ingredients in RESET taken immediately before sleep.
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