AvailOm®
Lysophospholipid DHA engineered for the brain’s dedicated Mfsd2a transporter — with preclinical evidence suggesting 2–10x greater neural uptake than standard fish oil for overnight inflammation resolution and synaptic membrane repair.
Primacy Research
What AvailOm® Does For You
Brain-Optimized DHA Delivery
Delivers DHA in lysophospholipid form — the exact substrate recognized by the brain’s dedicated Mfsd2a transporter — achieving 2–10x greater neural uptake compared to standard triglyceride or ethyl ester fish oil.
Active Inflammation Resolution
Membrane DHA is converted into resolvins, protectins, and maresins — specialized pro-resolving mediators that actively clear neuroinflammation rather than merely suppressing it.
Memory Support Studied in Clinical Trials
The MIDAS trial (n=485) showed 900 mg/day DHA reversed age-related memory decline equivalent to 3 years of cognitive aging. Stonehouse (2013) confirmed benefits in healthy young adults aged 18–45.
Synaptic Membrane Repair
DHA’s 22-carbon chain with 6 double bonds provides extreme conformational flexibility to synaptic membranes, optimizing receptor signaling, vesicle fusion kinetics, and lipid raft organization overnight.
Plant-Based Algal Source
Derived from algae rather than fish oil — eliminating ocean-borne contaminant concerns (heavy metals, PCBs) while providing the same brain-bioavailable DHA in a sustainable, vegetarian-compatible form.
Your Brain’s Resolution System Is Offline
DHA is the most abundant omega-3 fatty acid in your brain — comprising 15–20% of gray matter fatty acids by weight. Yet 68–95% of Western adults have suboptimal omega-3 status. Without adequate DHA, your brain cannot produce the specialized pro-resolving mediators that actively clear inflammation, and synaptic membranes progressively stiffen with every passing year.
Failed Resolution
Chronic neuroinflammation persists not because your immune system is overactive, but because the resolution phase never completes. Without DHA-derived resolvins, protectins, and maresins, inflammatory signals fire indefinitely — damaging the synaptic structures they were meant to protect.
Membrane Starvation
Brain synaptic membranes progressively lose DHA with age, replaced by inferior fatty acids like DPA n-6 that slow receptor signaling, impair vesicle fusion, and reduce the signal-to-noise ratio across every synapse in your neural architecture.
The BBB Bottleneck
Standard omega-3 supplements deliver DHA as triglyceride or ethyl ester — forms the blood-brain barrier barely recognizes. The brain’s dedicated DHA transporter (Mfsd2a) preferentially accepts lysophospholipid DHA. Most fish oil never reaches the neurons it’s meant to feed.
How AvailOm® Works
AvailOm® delivers DHA pre-formatted in lysophospholipid form — the brain’s preferred currency for BBB transport. This is the difference between shipping raw materials to a construction site and delivering pre-fabricated components ready for installation.
Mfsd2a Transporter Recognition
AvailOm® delivers DHA as lysophosphatidylcholine (LPC-DHA), the exact substrate recognized by Mfsd2a — a sodium-dependent symporter on brain endothelial cells identified by Nguyen et al. (Nature, 2014). Standard triglyceride DHA must be broken down, recirculated, and competes with beta-oxidation before reaching the brain. LPC-DHA bypasses this entirely.
Enhanced BBB Penetration & Neural Incorporation
Once transported across the BBB, LPC-DHA is incorporated directly into neuronal membrane phospholipids at the sn-2 position — the functional slot in phosphatidylserine, phosphatidylethanolamine, and phosphatidylcholine. Research shows LPC-DHA achieves 2–10x greater brain incorporation compared to equivalent doses in triglyceride or ethyl ester form.
Membrane Fluidity & Receptor Optimization
DHA’s 22-carbon chain with 6 double bonds (22:6n-3) creates extreme conformational flexibility in synaptic membranes. This increases lateral diffusion of signaling proteins, enhances receptor conformational changes, improves synaptic vesicle fusion kinetics, and modulates lipid raft organization — which is thought to make signaling faster and more efficient.
SPM Production — The Resolution Cascade
Membrane DHA is enzymatically converted into specialized pro-resolving mediators: Resolvin D1/D2 (block neutrophil infiltration, promote debris clearance), Neuroprotectin D1 (protects neurons from oxidative apoptosis, upregulates anti-apoptotic Bcl-2), and Maresins (promote tissue regeneration). This is active resolution — not suppression, but a biological “off switch” for inflammation.
BDNF Signaling Enhancement
DHA-enriched membranes optimize TrkB receptor trafficking, dimerization, and downstream Akt/CREB signaling. Neuroprotectin D1 directly upregulates BDNF expression in hippocampal neurons. Preclinical work suggests DHA doesn’t just build the structural substrate for learning — it may also amplify the growth factor signals that support neuroplasticity.
What the Research Shows
DHA’s cognitive and neuroprotective effects are among the most extensively studied in nutritional neuroscience — with large-scale RCTs, prospective cohorts, and the landmark Mfsd2a transporter discovery validating the lysophospholipid delivery advantage.
Yurko-Mauro K et al. (2010). Alzheimer’s & Dementia, 6(6):456–464. Healthy older adults (mean age ~70) with mild memory complaints, 900 mg/day algal DHA, 24 weeks. p=0.03.
Stonehouse W et al. (2013). American Journal of Clinical Nutrition, 97(5):1134–1143. Healthy adults aged 18–45, 1,160 mg DHA/day, 6 months. Episodic memory improvement in women; reaction time improvement in both sexes.
Douaud G et al. (2013). Proceedings of the National Academy of Sciences, 110(23):9523–9528. Elderly subjects with MCI; B-vitamin neuroprotection was almost entirely confined to participants with high baseline omega-3 levels. Omega-3 status is the gatekeeper for B-vitamin efficacy.
Tan ZS et al. (2012). Neurology, 78(9):658–664. Framingham Offspring Cohort. Lowest DHA quartile showed smaller total brain volumes, greater white matter hyperintensities, and lower scores on visual memory, executive function, and abstract thinking.
Your Nightly Dose in RESET
Why this dose works: The MIDAS trial demonstrated cognitive benefits at 900 mg/day DHA in standard triglyceride form. RESET delivers ~500 mg DHA in lysophospholipid form, which exploits the Mfsd2a transporter for 2–10x greater brain incorporation (Nguyen et al., Nature 2014; Lagarde et al.). This means based on preclinical absorption data, effective brain delivery may approach that of higher conventional doses, though human equivalence has not been established in clinical trials. Plant-based algal sourcing eliminates ocean-borne contaminant concerns (heavy metals, PCBs) and is suitable for vegetarian protocols.
The Kennedy Pathway Triad — APEX + RESET Combined Protocol
The Kennedy pathway is the primary biosynthetic route for phosphatidylcholine — the most abundant phospholipid in synaptic membranes. APEX provides choline + CTP during peak daytime demand; RESET provides DHA during overnight membrane remodeling. Wurtman et al. (MIT) showed the combination of all three substrates produces synergistic increases in synaptic membrane synthesis and dendritic spine density.
How AvailOm® Connects Across the System
AvailOm® is the structural linchpin of the Primacy protocol — connecting overnight inflammation resolution, membrane repair, and the circadian Kennedy Pathway Triad that spans both APEX and RESET.
The Kennedy Pathway Triad
APEX provides Citicoline (choline + cytidine) and Uridine (UTP → CTP) during the day to upregulate phosphatidylcholine synthesis enzymes. RESET provides AvailOm® DHA at night — the preferred sn-2 fatty acid for newly synthesized PC. Wurtman et al. (MIT) demonstrated that combining all three substrates produces synergistic increases in synaptic membrane synthesis, dendritic spine density, and neurite outgrowth that far exceed any single substrate alone. The circadian distribution is designed so substrate availability tracks the brain’s natural demand cycle.
The B-Vitamin Gatekeeper Effect
Douaud et al. (2013, PNAS) showed that APEX’s B-vitamin complex (B6/P5P, B12, Folate) only protects brain gray matter when omega-3 status is adequate — reducing atrophy by up to 73% in AD-vulnerable regions. Without sufficient DHA, B vitamins provide virtually no structural brain protection despite lowering homocysteine. RESET’s AvailOm® DHA is designed to help meet the omega-3 threshold, positioned to support the neuroprotective potential of APEX’s methylation stack.
Complete Inflammation Management
CherryPURE® inhibits COX-1/COX-2 to block new inflammatory cascades (initiation suppression). AvailOm® DHA provides the substrate for resolvins, protectins, and maresins that actively clear existing inflammation (resolution). Levagen® PEA acts through the endocannabinoid system via PPAR-alpha and indirect CB2 modulation — a third, non-overlapping anti-inflammatory pathway. Together, they are designed to form a three-phase overnight inflammation management system: suppress, resolve, and support recovery.
PS-DHA Assembly Complex
The predominant phosphatidylserine species in the brain is PS-DHA (PS with DHA at sn-2). Actiserine® provides the PS scaffold, L-Serine provides the amino acid headgroup, and AvailOm® DHA provides the preferred fatty acid tail. S-Acetyl Glutathione + Pycnogenol® form a layered antioxidant shield protecting DHA’s six double bonds from peroxidation — preserving membrane integrity during overnight repair.
Key Takeaways
Lysophospholipid DHA — The Brain’s Preferred Currency
AvailOm® delivers DHA pre-formatted for the Mfsd2a transporter — the brain’s dedicated DHA import channel discovered by Nguyen et al. (Nature, 2014). Standard fish oil delivers DHA in forms the BBB barely recognizes. This isn’t a marginal improvement; it’s a 2–10x difference in neural uptake.
Active Resolution, Not Just Suppression
DHA is the precursor to resolvins, protectins, and maresins — specialized pro-resolving mediators that actively clear inflammation rather than merely blocking it. This is the biological “off switch” that 68–95% of adults lack due to omega-3 deficiency.
The Third Substrate in the Kennedy Pathway Triad
APEX provides Citicoline and Uridine during the day. RESET provides AvailOm® DHA at night. Together, they deliver all three substrates for phosphatidylcholine synthesis — the primary membrane phospholipid in synapses — distributed across the circadian cycle to match the brain’s natural demand.
The Omega-3 Gatekeeper for B-Vitamin Neuroprotection
Douaud et al. (2013) demonstrated that B vitamins protect brain gray matter only when omega-3 status is adequate — up to 73% atrophy reduction with high omega-3, versus virtually zero without it. AvailOm® in RESET is positioned to support the neuroprotective potential of every B vitamin in APEX. Each product’s efficacy may be conditional on the other.
Frequently Asked Questions
What is AvailOm®?
AvailOm® is a high-DHA algal omega-3 ingredient that delivers DHA in lysophospholipid form (LPC-DHA). This is the exact molecular format recognized by Mfsd2a, the brain’s dedicated DHA transporter. Standard fish oil delivers DHA as triglyceride or ethyl ester — forms the blood-brain barrier barely recognizes.
How is AvailOm® different from regular fish oil?
Standard fish oil delivers DHA in triglyceride or ethyl ester form, which must be broken down, recirculated, and competes with beta-oxidation before reaching the brain. AvailOm® delivers DHA pre-formatted as lysophosphatidylcholine — bypassing this bottleneck entirely and achieving 2–10x greater brain incorporation per milligram.
How much DHA does RESET provide?
RESET delivers 1,000 mg of AvailOm® 50 High DHA Algae per serving, standardized to 50% DHA content, yielding approximately 500 mg of DHA in lysophospholipid form. Based on preclinical absorption data, effective brain delivery may approach that of higher conventional doses, though human equivalence has not been established in clinical trials.
Why is DHA important for the brain?
DHA comprises 15–20% of gray matter fatty acids and is essential for synaptic membrane fluidity, receptor signaling, and the production of specialized pro-resolving mediators that clear neuroinflammation. Low DHA status (affecting 68–95% of Western adults) is associated with smaller brain volumes, greater white matter damage, and accelerated cognitive aging.
What is the Kennedy Pathway connection?
The Kennedy pathway is the primary biosynthetic route for phosphatidylcholine — the most abundant phospholipid in synaptic membranes. APEX provides choline (Citicoline) and UTP (Uridine) during the day; RESET provides DHA (AvailOm®) at night as the sn-2 fatty acid. This circadian triad delivers all three substrates for synergistic membrane synthesis.
Is AvailOm® suitable for vegetarians?
Yes. AvailOm® is derived from algae, not fish. It provides the same brain-bioavailable DHA without ocean-sourced contaminant concerns (heavy metals, PCBs, dioxins) and is suitable for vegetarian and vegan protocols.
References
- [1]Yurko-Mauro, K., McCarthy, D., Rom, D., Nelson, E. B., Ryan, A. S., Blackwell, A., Salem, N., & Stedman, M. (2010). Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimer’s & Dementia, 6(6), 456–464.View
- [2]Stonehouse, W., Conlon, C. A., Podd, J., Hill, S. R., Minihane, A. M., Haskell, C., & Kennedy, D. (2013). DHA supplementation improved both memory and reaction time in healthy young adults: A randomized controlled trial. The American Journal of Clinical Nutrition, 97(5), 1134–1143.View
- [3]Douaud, G., Refsum, H., de Jager, C. A., Jacoby, R., Nichols, T. E., Smith, S. M., & Smith, A. D. (2013). Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment. Proceedings of the National Academy of Sciences, 110(23), 9523–9528.View
- [4]Tan, Z. S., Harris, W. S., Beiser, A. S., Au, R., Himali, J. J., Debette, S., Pikula, A., DeCarli, C., Wolf, P. A., Vasan, R. S., Robins, S. J., & Seshadri, S. (2012). Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging. Neurology, 78(9), 658–664.View
Resolve. Repair. Rebuild.
AvailOm® is one of 25 active ingredients in RESET, engineered to work as a system — resolving daytime inflammation, repairing synaptic membranes, and providing the structural DHA that makes every other ingredient in the protocol more effective.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.