Research Foundation

Built by Researchers. Backed by Evidence.

Our Science Advisory Board includes leaders in cognitive neuroscience, human psychopharmacology, exercise physiology, and sleep optimization. Every ingredient is dosed at clinically-proven levels. Every claim is linked to published research.

4Science Advisory
Board Members

52Clinical Ingredients
Combined

100%Transparent
Labeling

30Day Money-Back
Guarantee

Science Advisory Board

4 scientists spanning neuroscience, psychopharmacology, exercise physiology, and sleep medicine

Meet the team

Research-Backed

52 clinical ingredients across APEX and RESET — each dosed at levels used in published human trials

See the evidence

Quality Certified

GMP certified, 3rd party tested, full label disclosure

View certifications

// The Circadian Protocol

Your Brain,
Day & Night

APEX fuels catecholaminergic and cholinergic peak performance during the day. RESET transitions to GABAergic and serotonergic recovery at night — completing the neurotransmitter cycle your biology demands.

APEX ACTIVE

HoverTap to explore ingredient pathways

APEX

AM Formula

APEX

Peak Cognitive Performance & Sustained Energy

Ingredients

Systems

Servings

5 DAYS ON / 2 DAYS OFF

Shop APEX →

Circadian
Protocol

PM Formula

RESET

Deep Recovery + Sleep Support

Ingredients

Systems

Servings

NIGHTLY USE

Shop RESET →

The Algorithm

How The Primacy Score Works

Think of it like VO2 Max for your brain. You have a cognitive ceiling — your maximum capacity. The Primacy Score tells you what percentage of that capacity you're actually accessing today.

The VO2 Max Analogy

VO2 Max measures your physical ceiling. The Primacy Score does the same for cognition—your cognitive ceiling vs. today's accessible output.

Physical

VO2 Max

Maximum oxygen uptake

≈

Cognitive

Primacy Score

Neural access percentage

P_score = [ (Recovery x 0.5) + (Cognitive x 0.35) + (Drive x 0.15) ] x Physical_multiplier

Neural Access (3 pillars) × Hormesis Modifier

50%

Recovery

Sleep quality & duration
HRV vs. baseline
Resting heart rate

35%

Cognitive Access

DCTT (daily output)
÷ PFTT (your ceiling)
= % of capacity

15%

Drive

Psychological drive
Self-reported affect (1–10)
Daily engagement & readiness

x0.96-1.05

Physical Load

Hormesis principle
Too little or too much
exercise affects cognition

Why We Ask About Sleep Quality

According to the latest research, your subjective evaluation of sleep is actually a better predictor of next-day performance than wearable sleep data alone. That's why Primacy combines both — your perceived sleep quality with objective HRV and heart rate metrics — for a more accurate Recovery score.

Expert Guidance

Science Advisory Board

Coming Soon

We're excited to introduce our Science Advisory Board members in the coming weeks.

Our Approach

Three Core Principles

Clinical Doses

We use the exact doses shown effective in human trials — not reduced amounts.

Branded ingredients with documented purity (Magtein®, Citicoline, NooLVL®, etc.)

Full Transparency

No proprietary blends. Every ingredient and dose listed clearly on the label.

3rd party tested, COAs available, GMP certified manufacturing

Evidence-Based

Human studies preferred. Every claim linked to peer-reviewed research.

Safety-first approach, GRAS ingredients, thorough interaction screening

Formulation Details

Ingredient Evidence

Formulations informed by cognitive neuroscience, human psychopharmacology, and sleep science — ensuring efficacy, safety, and synergy.

Daytime cognitive optimization formula with 28 research-backed ingredients for sustained focus, mental clarity, and brain health.

Ingredients

152mg

Caffeine

Research Library

47 ingredient deep dives covering every active in APEX and RESET. Each explores clinical evidence, mechanism of action, dose validation, and system-level synergies.

Focus & Memory

16 deep dives

APEX

Neuroplasticity · Cholinergic · Attention

Caffeine Architecture · Flow State · Catecholamines

View All Deep Dives

Metabolic & Mitochondrial

8 deep dives

APEX

ATP Production · Perfusion · Bioavailability

Cortisol Reset · GABAergic Calm · Melatonin Pathway

Neuro-Structural · Inflammation · Antioxidant

View All Deep Dives

Shared Infrastructure

3 deep dives

APEX + RESET

B6/P5P · Di-Mag Malate · AstraGin®

View All Deep Dives

Explore All 47 Deep Dives

Trust & Quality

Full Label Disclosure

3rd Party Tested

GMP Certified

Research References

4-Step Quality Control

Raw Material Testing

→

In-Process QC

→

Finished Analysis

→

3rd Party Verification

Measurement Science

Cognitive Testing Background

The scientific foundation behind our precision cognitive assessments.

DCTT: Daily Cognitive Typing Test

The DCTT is a research-grade cognitive assessment disguised as a typing test. It measures psychomotor efficiency across four phases: Calibration, Adaptive (easy), Complex (hard), and Winddown — extracting cognitive signals from typing performance.

Key metrics include Load Impact (how complexity affects speed), Bounce-Back (recovery capacity), and Fatigue Resistance — providing a robust daily signal of cognitive throughput that's sensitive to sleep, stress, and supplementation effects.

Key References

Eriksen & Eriksen (1974). Perception & Psychophysics Fan et al. (2002). Journal of Cognitive Neuroscience

PFTT: Psychomotor Fatigue Tolerance Test

The PFTT establishes your cognitive "VO2 Max" — your maximum processing capacity when fully rested and optimized. This 12-minute monthly assessment demands sustained focus and attention to find your true cognitive ceiling.

Monthly calibration allows us to express daily DCTT scores as Cognitive Access %: (DCTT ÷ PFTT) × 100. This shows not just how you perform, but what percentage of YOUR full capacity you're accessing today.

Key References

Dinges & Powell (1985). Psychophysiology Basner & Dinges (2011). Sleep

Verify It Yourself

Take our cognitive test. See your data. Decide for yourself.

Build Your Free Performance Profile →

Free • 2 minutes • No credit card required

Built by Researchers. Backed by Evidence.

Your Brain,Day & Night

How The Primacy Score Works

The VO2 Max Analogy

Science Advisory Board

Three Core Principles

Ingredient Evidence

Research Library

Trust & Quality

Cognitive Testing Background

Verify It Yourself

Your Brain,Day & Night

How The Primacy Score Works

The VO2 Max Analogy

Three Core Principles

Ingredient Evidence

Research Library

Trust & Quality

Cognitive Testing Background

Verify It Yourself

Your Brain,
Day & Night

Your Brain,
Day & Night