https://primacy.io/research-library/magtein https://img.youtube.com/vi/Dgo6VR-Fuus/maxresdefault.jpg Magtein® - (Magnesium L-Threonate) The only form of magnesium with published research demonstrating it crosses the blood-brain barrier and increases brain magnesium levels, with preclinical evidence for increased synaptic density in the prefrontal cortex and hippocampus. https://www.youtube.com/embed/Dgo6VR-Fuus 2026-01-01 yes https://primacy.io/research-library/cognatiq https://img.youtube.com/vi/17JRut3tQbI/maxresdefault.jpg CognatiQ® - (Coffea arabica Fruit Extract) The only coffee-derived ingredient shown in a controlled trial (n=25) to raise circulating serum BDNF by 143% at 60 minutes — activating the brain’s primary growth and repair signal through a polyphenol pathway, not caffeine. https://www.youtube.com/embed/17JRut3tQbI 2026-01-01 yes https://primacy.io/research-library/sabroxy https://img.youtube.com/vi/gdcmxjQHizI/maxresdefault.jpg Sabroxy® - (Oroxylum indicum) A multi-pathway nootropic that simultaneously inhibits dopamine reuptake, elevates BDNF, modulates GABA-A receptors, and suppresses neuroinflammation — through a single standardized plant extract. https://www.youtube.com/embed/gdcmxjQHizI 2026-01-01 yes https://primacy.io/research-library/ergox https://img.youtube.com/vi/_nJGEq6Oafo/maxresdefault.jpg ErgoX® - (Ergothioneine) The only antioxidant with its own dedicated mammalian transporter — selectively concentrated in the brain and mitochondria, where oxidative stress does the most irreversible damage. https://www.youtube.com/embed/_nJGEq6Oafo 2026-01-01 yes https://primacy.io/research-library/caffeine-system https://img.youtube.com/vi/5llaLtp-rw8/maxresdefault.jpg Caffeine System - Instant Coffee + Anhydrous blend A precision-dosed dual-source caffeine architecture — engineered to deliver clean, sustained adenosine blockade without the crash, anxiety, or tolerance escalation of standard caffeine supplementation. https://www.youtube.com/embed/5llaLtp-rw8 2026-01-01 yes https://primacy.io/research-library/l-theanine https://img.youtube.com/vi/IA5HAN7ZN4I/maxresdefault.jpg L-Theanine - L-Theanine The amino acid that transforms stimulation into focus — promoting alpha-wave activity, moderating cortisol, and selectively blocking the anxiogenic and vasoconstrictive effects of caffeine without diminishing alertness. https://www.youtube.com/embed/IA5HAN7ZN4I 2026-01-01 yes https://primacy.io/research-library/dynamine-teacrine https://img.youtube.com/vi/pPND9t_WlHQ/maxresdefault.jpg Dynamine™ + TeaCrine® - (Methylliberine 40% + Theacrine 40%) A complementary methylxanthine pair that extends the caffeine energy curve across three distinct timescales — without habituation, cardiovascular overstimulation, or the dependency cycle of caffeine alone. https://www.youtube.com/embed/pPND9t_WlHQ 2026-01-01 yes https://primacy.io/research-library/mct-powder https://img.youtube.com/vi/ZynQJUxb_H8/maxresdefault.jpg MCT Powder - (Organic C8, 58.5% caprylic acid) The most ketogenic MCT — C8 caprylic acid — providing the brain with a rapid, clean alternative fuel source that bypasses glucose metabolism and supports mitochondrial function through ketone body production. https://www.youtube.com/embed/ZynQJUxb_H8 2026-01-01 yes https://primacy.io/research-library/tyropure https://img.youtube.com/vi/tg6TTggHtpo/maxresdefault.jpg TyroPure™ - (Fermented L-Tyrosine) The rate-limiting precursor for dopamine, norepinephrine, and epinephrine — fermentation-purified to >99% L-enantiomer purity and paired with the full cofactor system needed to convert it into active neurotransmitters under cognitive demand. https://www.youtube.com/embed/tg6TTggHtpo 2026-01-01 yes https://primacy.io/research-library/salidropure https://img.youtube.com/vi/dGtaAXwbDkc/maxresdefault.jpg SalidroPURE™ - (Salidroside 98.5%) The highest-purity isolated salidroside extract available — produced via Phaffia rhodozyma fermentation at 98.5% standardization — targeting the HPA axis, healthy monoamine balance, and AMPK to build stress resilience, preserve catecholamines, and sustain cognitive performance under load. https://www.youtube.com/embed/dGtaAXwbDkc 2026-01-01 yes https://primacy.io/research-library/folate https://img.youtube.com/vi/HRV4kiJkm3A/maxresdefault.jpg Folate - (L-5-MTHF / Methylfolate) The already-active form of folate that bypasses the MTHFR bottleneck affecting ~40% of the population — driving SAMe production for neurotransmitter synthesis, DNA methylation, and myelin maintenance. https://www.youtube.com/embed/HRV4kiJkm3A 2026-01-01 yes https://primacy.io/research-library/b12 https://img.youtube.com/vi/nyYWfEg-pts/maxresdefault.jpg Vitamin B12 - (Methylcobalamin) 800 mcg of methylcobalamin — the bioactive form that drives the methylation cycle, prevents the methyl-folate trap, and maintains the myelin sheaths your neural conduction speed depends on. https://www.youtube.com/embed/nyYWfEg-pts 2026-01-01 yes https://primacy.io/research-library/citicoline https://img.youtube.com/vi/vCq3D-R-kpo/maxresdefault.jpg Citicoline - (CDP-Choline) 500 mg of CDP-Choline — the dual-function phospholipid precursor that fuels acetylcholine synthesis and builds synaptic membranes simultaneously, while increasing frontal lobe ATP by 14% in a small within-subjects study (n=16, no placebo control). https://www.youtube.com/embed/vCq3D-R-kpo 2026-01-01 yes https://primacy.io/research-library/cereboost https://img.youtube.com/vi/U0LOvTIRKLo/maxresdefault.jpg Cereboost® - (American Ginseng) 250 mg of clinically studied American ginseng extract — standardized to >10% ginsenosides — that improves working memory within 3 hours through cholinergic enhancement and glycemic modulation, without stimulatory side effects. https://www.youtube.com/embed/U0LOvTIRKLo 2026-01-01 yes https://primacy.io/research-library/uridine https://img.youtube.com/vi/8Vb1Brl-Apk/maxresdefault.jpg Uridine - (5'-Monophosphate) The nucleotide precursor that drives the Kennedy pathway for synaptic membrane synthesis — providing the CTP energy currency your brain needs to build the phospholipid membranes that every new synapse requires. https://www.youtube.com/embed/8Vb1Brl-Apk 2026-01-01 yes https://primacy.io/research-library/biopqq https://img.youtube.com/vi/_X0DaT6WAfk/maxresdefault.jpg BioPQQ® - (Pyrroloquinoline Quinone) One of the few widely available compounds with preclinical evidence for stimulating mitochondrial biogenesis — supporting new mitochondria via PGC-1α activation while cycling through 20,000 redox reactions per molecule (in vitro). https://www.youtube.com/embed/_X0DaT6WAfk 2026-01-01 yes https://primacy.io/research-library/alcar https://img.youtube.com/vi/-lCJguSgabA/maxresdefault.jpg ALCAR - (Acetyl-L-Carnitine HCl) 750 mg of the BBB-crossing carnitine form that shuttles fatty acids into mitochondria for energy production while donating acetyl groups to both the TCA cycle and acetylcholine synthesis — the molecular bridge between mitochondrial fuel and cholinergic cognition. https://www.youtube.com/embed/-lCJguSgabA 2026-01-01 yes https://primacy.io/research-library/na-r-ala https://img.youtube.com/vi/EBwxeG1EF34/maxresdefault.jpg Na-R-ALA - (Stabilized R-Alpha Lipoic Acid) 100 mg of the stabilized, bioactive R-enantiomer of alpha-lipoic acid — the universal antioxidant that recycles glutathione, vitamin C, vitamin E, and CoQ10 while serving as a mitochondrial enzyme cofactor. The master recycler of the antioxidant network. https://www.youtube.com/embed/EBwxeG1EF34 2026-01-01 yes https://primacy.io/research-library/noolvl https://img.youtube.com/vi/hnDCLUhhbqM/maxresdefault.jpg NooLVL® - (Inositol-Stabilized Arginine Silicate) 1,500 mg of inositol-stabilized arginine silicate — the patented nitric oxide precursor clinically shown to improve reaction time, cognitive flexibility, and sustained attention through a nitric oxide pathway that supports cerebral blood flow, independent of caffeine’s mechanism. https://www.youtube.com/embed/hnDCLUhhbqM 2026-01-01 yes https://primacy.io/research-library/cocoaniol https://img.youtube.com/vi/7wSVRdNqRVc/maxresdefault.jpg CocoaNol® - (High-Flavanol Cocoa) 1,000 mg of high-flavanol cocoa extract — the eNOS activator associated with improved neurovascular coupling, increased cerebral blood flow by 8% in healthy elderly adults (n=34), and improves cognitive processing speed by up to 29% in subjects with impaired neurovascular coupling at baseline. https://www.youtube.com/embed/7wSVRdNqRVc 2026-01-01 yes https://primacy.io/research-library/floraglo-lutein https://img.youtube.com/vi/ICSxu6PxJjs/maxresdefault.jpg FloraGLO® Lutein - (10% yielding 10 mg) 10 mg of the most clinically studied lutein — the macular pigment precursor and blood-brain barrier-crossing carotenoid associated with improved visual processing speed, contrast sensitivity, and cognitive performance across all ages. https://www.youtube.com/embed/ICSxu6PxJjs 2026-01-01 yes https://primacy.io/research-library/sodium-bicarbonate https://img.youtube.com/vi/XrXg8NQsjEY/maxresdefault.jpg Sodium Bicarbonate - Sodium Bicarbonate 357 mg of pharmaceutical-grade sodium bicarbonate — the alkalizing electrolyte that counteracts morning dehydration-induced cognitive impairment, where as little as 1.6% fluid loss degrades reaction time, working memory, and sustained attention before you notice thirst. https://www.youtube.com/embed/XrXg8NQsjEY 2026-01-01 yes https://primacy.io/research-library/ceylon-cinnamon https://img.youtube.com/vi/cK4m_5r_0TU/maxresdefault.jpg Ceylon Cinnamon - (Extract 10:1) 300 mg of 10:1 Ceylon cinnamon extract — equivalent to 3,000 mg of raw bark — the insulin sensitizer that reduces postprandial glucose spikes, supports AMPK activation, and protects cognitive performance from the blood sugar volatility that degrades sustained attention and working memory. https://www.youtube.com/embed/cK4m_5r_0TU 2026-01-01 yes https://primacy.io/research-library/b6-p5p https://img.youtube.com/vi/Jml1Bu3yV2w/maxresdefault.jpg Vitamin B6 - (P5P / Pyridoxal 5'-Phosphate) 24 mg of pyridoxal-5’-phosphate — the active coenzyme form of B6 that requires no hepatic conversion — split across AM and PM to support catecholamine synthesis during the day and serotonin/GABA production overnight, covering the full neurotransmitter cycle that drives cognitive performance and recovery. https://www.youtube.com/embed/Jml1Bu3yV2w 2026-01-01 yes https://primacy.io/research-library/di-mag-malate https://img.youtube.com/vi/57caMKNcTZ0/maxresdefault.jpg Di-Magnesium Malate - Di-Magnesium Malate Di-magnesium malate across APEX and RESET delivers both elemental magnesium for ATP cofactor support and malic acid as a direct Krebs cycle substrate — the dual-function compound that fuels mitochondrial energy production around the clock while contributing to the three-form magnesium architecture of the full Primacy protocol. https://www.youtube.com/embed/57caMKNcTZ0 2026-01-01 yes https://primacy.io/research-library/astragin https://img.youtube.com/vi/pyGkxdB8U0w/maxresdefault.jpg AstraGin® - (Panax notoginseng + Astragalus) 50 mg of AstraGin® in both APEX and RESET — the patented Astragalus and Panax notoginseng extract that upregulates intestinal transporter proteins to with manufacturer research suggesting improved bioavailability of select nutrients by up to 67% in preclinical models, ensuring the rest of the formula is actually absorbed. https://www.youtube.com/embed/pyGkxdB8U0w 2026-01-01 yes https://primacy.io/research-library/holixer https://img.youtube.com/vi/g-Mmo323Hj8/maxresdefault.jpg Holixer® - (Holy Basil Extract, 2.5% ursolic acid) 150 mg of holy basil extract standardized to 2.5% ursolic acid — a compound that has demonstrated 11β-HSD1 inhibition in preclinical models, the enzyme that reactivates cortisol in peripheral tissues and keeps your stress response elevated long after the stressor is gone. https://www.youtube.com/embed/g-Mmo323Hj8 2026-01-01 yes https://primacy.io/research-library/actiserine https://img.youtube.com/vi/qi3Js4vJUGk/maxresdefault.jpg Actiserine® - (Phosphatidylserine) 300 mg of phosphatidylserine — the membrane phospholipid with preliminary evidence for cortisol response modulation in a small trial (n=9), support neural membrane phospholipid status, and facilitate the synaptic vesicle fusion events that consolidate memory during sleep. https://www.youtube.com/embed/qi3Js4vJUGk 2026-01-01 yes https://primacy.io/research-library/pharmagaba https://img.youtube.com/vi/EjTyp8CVyNI/maxresdefault.jpg PharmaGABA® - PharmaGABA® The only naturally fermented form of GABA observed to increase alpha-wave activity within 60 minutes in a controlled crossover study (n=13) — working through the enteric nervous system and vagus nerve rather than relying on direct CNS penetration. https://www.youtube.com/embed/EjTyp8CVyNI 2026-01-01 yes https://primacy.io/research-library/lemon-balm https://img.youtube.com/vi/xYrlRzRcGsw/maxresdefault.jpg Lemon Balm - (Extract 5% rosmarinic acid) A GABA-transaminase inhibitor that extends your brain’s own calming signal — reducing anxiety and insomnia without sedation or cognitive impairment. https://www.youtube.com/embed/xYrlRzRcGsw 2026-01-01 yes https://primacy.io/research-library/magnolia-bark https://img.youtube.com/vi/8tNAsnWX024/maxresdefault.jpg Magnolia Bark - (90% Honokiol) A natural GABA-A receptor modulator that supports deep, restorative sleep architecture. Preclinical models suggest it promotes deep, restorative sleep without tolerance, dependency, or destroyed sleep architecture. https://www.youtube.com/embed/8tNAsnWX024 2026-01-01 yes https://primacy.io/research-library/mg-bisglycinate https://img.youtube.com/vi/mnokZkwq3EI/maxresdefault.jpg Mg Bisglycinate - (Albion® Chelate) TRAACS-verified chelated magnesium absorbed via the PepT1 dipeptide transporter — bypassing ionic competition to deliver dual-action CNS calming through both Mg and glycine co-delivery. https://www.youtube.com/embed/mnokZkwq3EI 2026-01-01 yes https://primacy.io/research-library/affron https://img.youtube.com/vi/P65zFE6A0Y8/maxresdefault.jpg Affron® - (Saffron Extract, Crocus sativus L.) The only patented saffron extract with a standardized Lepticrosalides® content — supported by clinical research across 6 RCTs for mood support, sleep improvement, and melatonin preservation through multi-pathway monoamine modulation and HPA axis regulation. https://www.youtube.com/embed/P65zFE6A0Y8 2026-01-01 yes https://primacy.io/research-library/zinc-bisglycinate https://img.youtube.com/vi/zvpA9KLqTkc/maxresdefault.jpg Zinc Bisglycinate - (Albion® Chelate, 20% Zn) A chelated zinc that absorbs through the PepT1 dipeptide transporter — bypassing mineral competition — to activate AANAT, the zinc-dependent enzyme that gates your melatonin production. https://www.youtube.com/embed/zvpA9KLqTkc 2026-01-01 yes https://primacy.io/research-library/cherrypure https://img.youtube.com/vi/s69DG-dgjuI/maxresdefault.jpg CherryPURE® - (Tart Cherry) A concentrated Montmorency tart cherry powder that delivers natural melatonin, inhibits the enzyme that degrades tryptophan, and supports a healthy inflammatory response — breaking the inflammation-insomnia cycle. https://www.youtube.com/embed/s69DG-dgjuI 2026-01-01 yes https://primacy.io/research-library/l-serine https://img.youtube.com/vi/TUfumGre4Uw/maxresdefault.jpg L-Serine - L-Serine A neuroprotective substrate shown safe at doses up to 30 g/day in clinical safety trials, with preliminary signals of benefit — feeding five critical brain pathways from myelin repair and membrane synthesis to overnight synaptic plasticity. https://www.youtube.com/embed/TUfumGre4Uw 2026-01-01 yes https://primacy.io/research-library/taurine https://img.youtube.com/vi/roXnTz-_H8I/maxresdefault.jpg Taurine - Taurine One of the body’s most abundant free amino acids — supports GABA and glycine receptor activity, cellular osmotic balance, and emerging geroprotector linked to healthspan in landmark research. https://www.youtube.com/embed/roXnTz-_H8I 2026-01-01 yes https://primacy.io/research-library/glycine https://img.youtube.com/vi/rPc09OQLt5U/maxresdefault.jpg Glycine - Glycine The thermoregulatory sleep trigger that lowers core body temperature to unlock deep sleep — while providing the primary structural amino acid for overnight collagen synthesis and glutathione production. https://www.youtube.com/embed/rPc09OQLt5U 2026-01-01 yes https://primacy.io/research-library/availom https://img.youtube.com/vi/mQDeVQRBoxI/maxresdefault.jpg AvailOm® - (50 High-DHA Algae Oil) Free fatty acid DHA complexed with L-lysine for direct absorption — clinically shown to deliver up to 8x greater EPA+DHA bioavailability than standard ethyl ester fish oil, powering overnight inflammation resolution and synaptic membrane repair. https://www.youtube.com/embed/mQDeVQRBoxI 2026-01-01 yes https://primacy.io/research-library/levagen https://img.youtube.com/vi/q6ukwWRNJUM/maxresdefault.jpg Levagen® - (PEA / Palmitoylethanolamide) A cold-water dispersible endocannabinoid modulator that resolves inflammation through the ALIA mechanism — with no reported tolerance or withdrawal effects in clinical trials to date, and 1.75x enhanced bioavailability via LipiSperse® technology. https://www.youtube.com/embed/q6ukwWRNJUM 2026-01-01 yes https://primacy.io/research-library/pycnogenol https://img.youtube.com/vi/MB1GL6C_q_c/maxresdefault.jpg Pycnogenol® - (Maritime Pine Bark) A multi-target procyanidin complex that activates eNOS for overnight cerebral blood flow, suppresses NF-kB to resolve inflammation, and upregulates Nrf2 antioxidant defense — rebuilding vascular architecture while you sleep. https://www.youtube.com/embed/MB1GL6C_q_c 2026-01-01 yes https://primacy.io/research-library/s-acetyl-glutathione https://img.youtube.com/vi/0a0378L2rOc/maxresdefault.jpg S-Acetyl Glutathione - S-Acetyl Glutathione The acetyl-protected form of the body’s most abundant intracellular antioxidant — engineered to survive GI degradation and deliver intact, reduced glutathione directly inside your cells. https://www.youtube.com/embed/0a0378L2rOc 2026-01-01 yes https://primacy.io/research-library/selenium https://img.youtube.com/vi/0-T6VgFH82g/maxresdefault.jpg Selenium - (L-selenomethionine) The essential trace mineral that powers 25 selenoproteins — including glutathione peroxidase and thioredoxin reductase — forming the enzymatic core of overnight antioxidant defense. https://www.youtube.com/embed/0-T6VgFH82g 2026-01-01 yes https://primacy.io/research-library/copper-bisglycinate https://img.youtube.com/vi/QNrvsnfVgts/maxresdefault.jpg Copper Bisglycinate - (Chelate) The essential cofactor for superoxide dismutase 1 (SOD1) — the primary cytosolic antioxidant enzyme — delivered as a bisglycinate chelate for superior absorption via the PepT1 dipeptide transporter. https://www.youtube.com/embed/QNrvsnfVgts 2026-01-01 yes https://primacy.io/research-library/ubiqsome-coq10 https://img.youtube.com/vi/NLj-I-mV4vo/maxresdefault.jpg Ubiqsome® CoQ10 - (Enhanced-absorption Ubiquinol) The only form of CoQ10 demonstrated in pharmacokinetic studies to achieve 3–5x higher bioavailability than standard ubiquinone (Indena S.p.A. manufacturer data) — delivering the mitochondrial electron carrier and membrane antioxidant that powers overnight cellular energy synthesis and repair. https://www.youtube.com/embed/NLj-I-mV4vo 2026-01-01 yes https://primacy.io/research-library/neoaxt-astaxanthin https://img.youtube.com/vi/ihMzxjSpOWY/maxresdefault.jpg NeoAXT™ - (Fermented Astaxanthin) Among the most potent lipid-soluble carotenoid antioxidants measured in vitro for singlet oxygen quenching — produced via Phaffia rhodozyma yeast fermentation and physically integrated into mitochondrial membranes to provide transmembrane singlet oxygen quenching, Nrf2 activation, and NF-κB inhibition during overnight recovery. https://www.youtube.com/embed/ihMzxjSpOWY 2026-01-01 yes https://primacy.io/research-library/digeseb https://img.youtube.com/vi/8Bd3_SqpY_Q/maxresdefault.jpg DigeSEB® - (Super Enzyme Blend) A pH-stable, full-spectrum digestive enzyme blend delivering lipase, protease, cellulase, amylase, and lactase — engineered to maximize fat-soluble compound absorption, accelerate protein breakdown, and eliminate digestive bottlenecks during RESET’s overnight recovery protocol. https://www.youtube.com/embed/8Bd3_SqpY_Q 2026-01-01 yes